Hepatoblastomas present as a rapidly growing singular well-circumscribed solid mass. They are more common in the right hepatic lobe. Due to rapid growth, rupture and hemorrhage are potentially deadly complications if unrecognized. Microscopically, these tumors are composed of embryonal and fetal hepatic elements. Prognosis is based on histologic type, with well-differentiated pure tumors having the best prognosis and poorly differentiated small cell tumors having the worst prognosis.
Symptoms include abdominal swelling, abdominal pain, vomiting, poor feeding or feeding intolerance, weight loss, anorexia, and irritability. Serum alpha fetoprotein (AFP) is elevated in 80%-90% of patients. Tumor rupture may present with vomiting, peritonitis, and severe anemia.
C22.2 – Hepatoblastoma
109843000 – Hepatoblastoma
Differential Diagnosis & Pitfalls