Contents

SynopsisCodesDiagnostic PearlsDifferential Diagnosis & PitfallsBest TestsDrug Reaction DataReferences
Immune-mediated necrotizing myopathy
Print
Other Resources UpToDate PubMed

Immune-mediated necrotizing myopathy

Print Images (1)
Contributors: Benjamin L. Mazer MD, MBA
Other Resources UpToDate PubMed

Alerts and Notices

Synopsis

Immune-mediated necrotizing myopathy : Proximal muscle weakness, Symmetric extremities distribution, HMG-CoA reductase inhibitor, Dyspnea, CPK elevated
Immune-mediated necrotizing myopathy (IMNP) is a recently described, very rare inflammatory myopathy in the same category as dermatomyositis and polymyositis. Like those diseases, it presents with proximal muscle weakness and elevated muscle enzymes. IMNP is caused by autoantibodies that recognize "anti-signal recognition particle." A small number of cases are attributed to statin use producing antibodies to HMG-CoA reductase.

Muscle biopsy shows muscle fiber necrosis without inflammatory cells.

Immunosuppressive medications, including corticosteroids, intravenous immunoglobulin (IVIG), and rituximab, are used to treat the disease. Statins should be discontinued in cases associated with these drugs.

Codes

ICD10CM:
G72.49 – Other inflammatory and immune myopathies, not elsewhere classified

SNOMEDCT:
715863001 – Autoimmune necrotizing myopathy

Diagnostic Pearls

Subscription Required

Differential Diagnosis & Pitfalls

Best Tests

Subscription Required

Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

Subscription Required

References

Subscription Required

Last Updated:10/31/2019
Copyright © 2023 VisualDx®. All rights reserved.
Immune-mediated necrotizing myopathy
Print  
A medical illustration showing key findings of Immune-mediated necrotizing myopathy : Proximal muscle weakness, Symmetric extremities distribution, HMG-CoA reductase inhibitor, Dyspnea, CPK elevated
Copyright © 2023 VisualDx®. All rights reserved.