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Infiltrating basal cell carcinoma
See also in: Hair and Scalp
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Infiltrating basal cell carcinoma

See also in: Hair and Scalp
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Contributors: William M. Lin MD, Susan Burgin MD, Noah Craft MD, PhD, Lowell A. Goldsmith MD, MPH
Other Resources UpToDate PubMed

Synopsis

Basal cell carcinoma (BCC) is a neoplasm of basal keratinocytes and the most common skin cancer. It is largely a non-metastasizing form of cancer. The 4 major subtypes of BCC are infiltrating, nodular, pigmented, and superficial. BCC is typically limited to areas on the head, neck, face, and nose but can occur at any location.

Infiltrating or morpheaform BCCs can be extensive and locally destructive, and require extensive plastic surgical repair if not treated early.

Risk factors for BCCs in general include light skin phototype, sun exposure, radiation, advanced age, immunosuppression, and a personal history of non-melanoma skin cancer. Hereditary conditions associated with BCCs in general include albinism, xeroderma pigmentosum, nevoid basal cell carcinoma syndrome, Rasmussen syndrome, Rombo syndrome, Bazex-Dupré-Christol syndrome, and Darier disease.

The molecular pathogenesis of BCC formation is just beginning to be understood. The primary pathway that appears to be dysregulated is the sonic-hedgehog pathway that normally regulates early embryonic development. Mutations in this pathway, particularly inactivation of PTCH1 as seen in nevoid basal cell carcinoma syndrome or sporadic activating mutations in SMO, lead to BCC formation.

Codes

ICD10CM:
C44.91 – Basal cell carcinoma of skin, unspecified

SNOMEDCT:
402527000 – Basal cell carcinoma - infiltrative

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

Best Tests

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Management Pearls

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Therapy

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Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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References

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Last Updated: 10/10/2018
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Infiltrating basal cell carcinoma
See also in: Hair and Scalp
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Infiltrating basal cell carcinoma : Face, Skin ulcer, Superior chest, Upper back, Atrophic scar
Clinical image of Infiltrating basal cell carcinoma
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