Keratosis pilaris is an exceedingly common, benign skin disorder of the follicular orifice. Small follicular papules arise due to the retention of keratin at the follicular opening. The most commonly affected areas are the posterior upper arms and thighs, although cheeks and buttocks may also be involved. Keratosis pilaris is seen more frequently in children and adolescents. It is more common in atopic individuals and, frequently, there is a family history of the condition.
Keratosis pilaris tends to worsen during winter months, and it usually decreases after puberty. It is typically asymptomatic, but if treatment is attempted, the affected areas are often refractory.
Facial lesions may be confused with milia or acne – Milia are yellow-white, chalky, nonfollicular, hemispherical, smooth-surfaced papules. Acne is characterized by comedones, inflammatory papules, and pustules.
Lichen spinulosus – Grouped keratotic spiny follicular papules coalescing to form nummular or circular plaques on the trunk and extremities.
Phrynoderma (vitamin A deficiency) – Large individual keratotic horny papules on the buttocks, shoulders, and around the elbows and knees; there may be an underling nutritional deficiency.
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Drug Reaction Data
Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.
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