Large cell acanthoma is a relatively uncommon, benign neoplasm considered to be a subtype of solar lentigo or seborrheic keratosis. It typically presents as a scaly, tan macule or thin plaque on photodamaged skin, usually in elderly patients. Large cell acanthomas are characteristically solitary or few in number.

The etiology is unknown but thought to be related to extensive ultraviolet (UV) exposure. Analysis of clinical, histologic, and immunohistochemical properties suggests that the large cell acanthoma represents a reaction pattern evolving from a solar lentigo.