Monoclonal gammopathy of undetermined significance
Alerts and Notices
Synopsis

Several dermatoses are associated with MGUS including scleromyxedema, primary systemic amyloidosis, and normolipemic plane xanthomas. Additionally, erythema elevatum diutinum, subcorneal pustular dermatosis, scleredema, and acquired angioedema (C1 inhibitor deficiency) may have an underlying monoclonal gammopathy. Schnitzler syndrome and POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, multiple myeloma, and skin changes and sclerotic bone changes) are rare syndromes that are seen in the setting of MGUS.
Codes
ICD10CM:D47.2 – Monoclonal gammopathy
SNOMEDCT:
35601003 – Monoclonal gammopathy of undetermined significance
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Diagnostic Pearls
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Differential Diagnosis & Pitfalls
MGUS should be distinguished from the following:- Multiple myeloma
- Amyloidosis
- Waldenström macroglobulinemia
- Idiopathic Bence Jones proteinuria
- Non-Hodgkin lymphoma
- Inflammatory disorders such as autoimmune diseases (systemic lupus erythematosus, rheumatoid arthritis)
- Hepatitis C virus infection
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References
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Last Reviewed:01/31/2019
Last Updated:02/10/2019
Last Updated:02/10/2019