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Non-Hodgkin lymphoma in Adult
See also in: Oral Mucosal Lesion
Other Resources UpToDate PubMed

Non-Hodgkin lymphoma in Adult

See also in: Oral Mucosal Lesion
Contributors: Nina Haghi MD, Susan Burgin MD, Paritosh Prasad MD
Other Resources UpToDate PubMed

Synopsis

Non-Hodgkin lymphoma (NHL) refers to a very broad group of malignancies involving the lymphatic system. It excludes Hodgkin lymphoma, which is less common.

NHLs are subclassified based on the different types of lymphocytes involved. They can include B-lymphocytes, T-lymphocytes, and natural killer cells. B-cell lymphomas are the most common and include diffuse B-cell lymphoma, cutaneous B-cell lymphoma, follicular lymphoma, chronic lymphocytic leukemia, acute lymphocytic leukemia, mantle cell lymphoma, marginal zone lymphomas, Burkitt lymphoma, lymphoplasmacytic lymphoma, and central nervous system lymphoma. T-cell lymphomas include peripheral T-cell lymphoma, anaplastic large cell lymphoma, angioimmunoblastic T-cell lymphoma, and adult T-cell lymphoma / leukemia.

The signs and symptoms of NHL are very heterogeneous, depending on the subtype of malignancy. It can involve lymph nodes, skin, the gastrointestinal system, the liver, the spleen, bone marrow, or any other part of the body.

It is critical to diagnose the type of NHL in order to correctly treat it.

Codes

ICD10CM:
C85.90 – Non-Hodgkin lymphoma, unspecified, unspecified site

SNOMEDCT:
118601006 – Non-Hodgkin's lymphoma

Look For

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

  • Reactive lymphadenopathy (infectious, autoimmune, drug-induced)
  • Hodgkin lymphoma
  • Other malignancy

Best Tests

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Management Pearls

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Therapy

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Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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References

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Last Reviewed:03/18/2021
Last Updated:03/31/2021
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Non-Hodgkin lymphoma in Adult
See also in: Oral Mucosal Lesion
Non-Hodgkin lymphoma : Fever, Night sweats, Generalized lymphadenopathy, Smooth nodule
Clinical image of Non-Hodgkin lymphoma
A close-up of numerous smooth, dull, pink papules.
Copyright © 2021 VisualDx®. All rights reserved.