Opsoclonus-myoclonus syndrome in Adult
Alerts and Notices
Synopsis
OMS may be autoimmune, postinfectious, postvaccination, or paraneoplastic in etiology. In adults, OMS can be associated with breast cancer or small cell lung carcinoma. In children, nearly half of those diagnosed with OMS are found to have an occult neuroblastoma. In children with OMS without an associated neuroblastoma, the cause is often not identified.
Disease onset tends to be subacute. In children, the course is often relapsing. The majority of affected children have long-term sequelae, including motor, behavioral, and cognitive deficits. Most adults achieve complete remission with therapy of the underlying cause.
Codes
ICD10CM:H55.89 – Other irregular eye movements
SNOMEDCT:
230350000 – Opsoclonus-myoclonus syndrome
Look For
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Diagnostic Pearls
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Differential Diagnosis & Pitfalls
- Acute cerebellar ataxia – This diagnosis is more likely if end-gaze nystagmus is present.
- Acute cerebellitis
- Seizures
- Acute disseminated encephalomyelitis (ADEM)
- Cerebellar malignancy
- Intoxication or ingestion
- Cerebellar infarction
- Spinocerebellar ataxias
Best Tests
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Management Pearls
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Therapy
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References
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Last Reviewed:08/27/2018
Last Updated:04/22/2019
Last Updated:04/22/2019