Orofacial herpes simplex virus in Infant/Neonate
Childhood infection is common via child-to-child contact or kissing by a parent.
B00.1 – Herpesviral vesicular dermatitis
235055003 – Oral herpes simplex infection
- Differentiate from zoster, which also presents with umbilicated vesicles. Herpes zoster presents unilaterally in general without crossing the midline; culture differentiates between the two.
- Molluscum contagiosum
- Fixed drug eruption
- Insect bites
- Contact dermatitis (irritant, allergic)
- Contact stomatitis – A history of recurrent ulcers or blisters caused by contactant differentiates between the two.
- Herpangina – This tends to occur in spring or fall and in epidemics. Oral ulcers tend to localize to the back of the mouth and oropharynx.
- Aphthous stomatitis – This is a common recurrent ulcerative condition most often misdiagnosed as recrudescent herpes infection. Aphthous ulcers almost always involve only the nonkeratinized mucosa while recrudescent herpes simplex almost always involves the keratinized mucosa in healthy hosts.
- Erythema multiforme – A history of herpes simplex infection is often elicited 2-3 weeks prior to the appearance of these oral ulcers.
- Oral erosive lichen planus
- Hand-foot-and-mouth disease – Involvement of the palm and dorsa of feet is characteristic.
- Stomatitis associated with chemotherapy (see chemotherapy-induced mucositis) – These lesions occur within 7-10 days of the beginning of chemotherapy; however, HSV may recrudesce within these lesions.
- Stevens-Johnson syndrome – Typical skin findings as well as severe oral ulcerations differentiate this from herpes simplex infection.
- Behçet syndrome