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Paraneoplastic cerebellar degeneration
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Paraneoplastic cerebellar degeneration

Contributors: Jamie Adams MD, Richard L. Barbano MD, PhD
Other Resources UpToDate PubMed

Synopsis

Paraneoplastic cerebellar degeneration is a disorder caused by an immune-mediated attack of cerebellar cells by cross-reacting antibodies to target tumor cells. It is most commonly seen in ovarian cancer, uterine cancer, breast cancer, Hodgkin lymphoma, and small cell lung carcinoma. Anti-Yo, anti-Tr, and anti-Hu are some of the known antibodies that cause the disorder.

Early symptoms include nausea and dizziness. Symptoms progress over days to months to include vertigo, nystagmus, ataxia, and dysarthria. Some syndromes may also present with concomitant encephalopathy. Prognosis depends on early diagnosis and treatment of the underlying malignancy.

Codes

ICD10CM:
G32.81 – Cerebellar ataxia in diseases classified elsewhere

SNOMEDCT:
192877007 – Paraneoplastic cerebellar degeneration

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Differential Diagnosis & Pitfalls

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Therapy

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References

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Last Reviewed:07/24/2019
Last Updated:07/25/2019
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Paraneoplastic cerebellar degeneration
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Paraneoplastic cerebellar degeneration : Dizziness, Nausea, Ataxia, Dysarthria, Gait disturbance, Nystagmus, Vertigo
Copyright © 2022 VisualDx®. All rights reserved.