Pigmented basal cell carcinoma
Risk factors for BCCs in general include light skin phototype, sun exposure, radiation, advanced age, immunosuppression, and a personal history of non-melanoma skin cancer. The molecular pathogenesis of BCC formation is just beginning to be understood. The primary pathway that appears to be dysregulated is the sonic-hedgehog pathway that normally regulates early embryonic development. Mutations in this pathway, particularly inactivation of PTCH1 as seen in nevoid basal cell carcinoma syndrome or sporadic activating mutations in SMO, lead to BCC formation.
Hereditary conditions associated with BCCs in general include albinism, xeroderma pigmentosum, nevoid basal cell carcinoma syndrome, Rasmussen syndrome, Rombo syndrome, Bazex-Dupré-Christol syndrome, and Darier disease.
C44.91 – Basal cell carcinoma of skin, unspecified
403909004 – Pigmented basal cell carcinoma
- Melanocytic nevus including dysplastic nevus
- Seborrheic keratosis – often has textural changes not typical of pigmented BCCs
- Pigmented actinic keratosis – often has textural changes not typical of pigmented BCCs
- Melanoma including lentigo maligna
- Blue nevus
- Atypical fibroxanthoma
- Vascular proliferations – eg, hemangioma or lobular capillary hemangioma (pyogenic granuloma)