Pigmented basal cell carcinoma
There are many subtypes of BCC, including superficial, nodular, and infiltrating. Any of these subtypes can be pigmented, but the nodular subtype comprises the majority of pigmented BCCs. Overall, approximately 7% of BCCs are pigmented. Pigmented BCCs can occur in any location but are most commonly found on the head and neck.
The greatest risk factor contributing to the development of BCCs is sun exposure, and people with light skin phototypes are at higher risk. Intermittent sun exposure is more closely associated with the development of BCCs than cumulative ultraviolet (UV) exposure.
Other risk factors for BCCs include environmental exposure (ie, ionizing radiation, indoor tanning, chemicals such as arsenic, psoralen plus UVA, and coal tar), phenotype (freckling, red hair, fair skin that always burns and never tans), immunosuppression such as organ transplantation (which results in a 5-10 times higher risk of BCCs than the general population), and various genetic syndromes including xeroderma pigmentosum, oculocutaneous albinism, Muir-Torre syndrome, basal cell nevus syndrome (Gorlin syndrome), Rombo syndrome, and Bazex-Dupré-Christol syndrome. The gene most frequently altered in BCCs is the PTCH1 gene, followed by the TP53 gene.
Although BCCs are almost never fatal, local tissue destruction and disfiguration do occur. The metastasis rate is approximately 1 in 35 000. Metastasis is rare and typically occurs through perineural spread, lymph node metastasis, and then lung / bone metastasis.
C44.91 – Basal cell carcinoma of skin, unspecified
403909004 – Pigmented basal cell carcinoma
- Melanocytic nevus including dysplastic nevus
- Seborrheic keratosis – often has textural changes not typical of pigmented BCCs
- Pigmented actinic keratosis – often has textural changes not typical of pigmented BCCs
- Melanoma including lentigo maligna
- Blue nevus
- Deep penetrating nevus
- Atypical fibroxanthoma
- Vascular proliferations – eg, hemangioma, angiokeratoma, or lobular capillary hemangioma (pyogenic granuloma)
- Basosquamous carcinoma
Last Updated: 06/26/2020