Proctitis often occurs in adults with receptive anal exposures (oral, digital, or genital to anal). Neisseria gonorrhoeae, Chlamydia trachomatis (including lymphogranuloma venereum [LGV] serovars), herpes simplex virus (HSV), and Treponema pallidum are the most common sexually transmitted pathogens. Proctitis can also be caused by nonsexually transmitted infections, autoimmune diseases, ischemia, vasculitis, trauma, radiation (see radiation proctitis), or medication side effects. In addition, it can affect adults with inflammatory bowel disease (eg, Crohn disease, ulcerative colitis).
Treatment depends on the cause and ranges from antibiotic or antiviral therapy to anti-inflammatory or immunosuppressive therapy.
K62.89 – Other specified diseases of anus and rectum
3951002 – Proctitis
Differential Diagnosis & Pitfalls
- Inflammatory bowel disease (Crohn disease, ulcerative colitis)
- Anal trauma
- Infection – sexually and nonsexually transmitted infections, such as Salmonella, Shigella, Campylobacter, Escherichia coli, Clostridioides (formerly Clostridium) difficile, or amebiasis
- Radiation proctitis
Drug Reaction Data