Common causes of pseudo-Cushing syndrome include pregnancy, alcohol use disorder, morbid obesity, polycystic ovarian syndrome, end-stage renal disease, severe major depressive disorder, and poorly controlled diabetes. Treatment of the underlying illness will resolve the pseudo-Cushing syndrome.
E27.0 – Other adrenocortical overactivity
237737000 – Pseudo-cushing's syndrome
Differential Diagnosis & Pitfalls
- Cushing syndrome – Differentiated from pseudo-Cushing syndrome by two abnormal first-line tests, which include 24-hour urinary free cortisol (UFC) excretion, overnight 1 mg dexamethasone suppression test (DST), CRH after dexamethasone test, late-night salivary cortisol, and late-night serum cortisol.