Contents

SynopsisCodesLook ForDiagnostic PearlsDifferential Diagnosis & PitfallsBest TestsManagement PearlsTherapyDrug Reaction DataReferences
Potentially life-threatening emergency
Thyroid storm
Other Resources UpToDate PubMed
Potentially life-threatening emergency

Thyroid storm

Contributors: Casey Silver MD, Abhijeet Waghray MD
Other Resources UpToDate PubMed

Synopsis

Thyroid storm is a rare, life-threatening disorder of the thyroid characterized by sudden-onset thyrotoxicosis. It is often caused by an acute event such as thyroid surgery, trauma, infection, or iodine load. It may also be caused by oversecretion of thyroid hormone or sudden reduction in thyroid-suppression medication.

Common signs and symptoms include high fever, tachycardia, congestive heart failure, arrhythmia, altered mental status, agitation, tremor, diarrhea, confusion, and sweating.

Management consists of reducing fever, reducing thyroid-hormone release, and identifying and limiting causal factors.

Codes

ICD10CM:
E05.91 – Thyrotoxicosis, unspecified with thyrotoxic crisis or storm

SNOMEDCT:
29028009 – Thyrotoxic crisis

Look For

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

  • Thyrotoxicosis without storm – Thyroid storm is based on the severity of symptoms.
Thyroid function tests (especially free T4 and T3) should be normal in other causes of fever:

Best Tests

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Management Pearls

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Therapy

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Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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References

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Last Reviewed:07/01/2019
Last Updated:07/02/2019
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Potentially life-threatening emergency
Thyroid storm
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A medical illustration showing key findings of Thyroid storm : Altered mental state, Diarrhea, Vomiting, Tachycardia, Goiter, Tremor, BP increased, Bibasilar crackles, Hyperpyrexia
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