Thyroid storm is a rare, life-threatening disorder of the thyroid characterized by sudden-onset thyrotoxicosis. It is often caused by an acute event such as thyroid surgery, trauma, infection, or iodine load. It may also be caused by oversecretion of thyroid hormone or sudden reduction in thyroid-suppression medication.
Common signs and symptoms include high fever, tachycardia, congestive heart failure, arrhythmia, altered mental status, agitation, tremor, diarrhea, confusion, and sweating.
Management consists of reducing fever, reducing thyroid-hormone release, and identifying and limiting causal factors.
ICD10CM: E05.91 – Thyrotoxicosis, unspecified with thyrotoxic crisis or storm
SNOMEDCT: 29028009 – Thyrotoxic crisis
Differential Diagnosis & Pitfalls
Thyrotoxicosis without storm – Thyroid storm is based on the severity of symptoms.
Thyroid function tests (especially free T4 and T3) should be normal in other causes of fever:
Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.