ContentsSynopsisCodesLook ForDiagnostic PearlsDifferential Diagnosis & PitfallsBest TestsManagement PearlsTherapyDrug Reaction DataReferencesView all Images (26)
Transient acantholytic dermatosis
Print Captions OFF
Other Resources UpToDate PubMed

Transient acantholytic dermatosis

Print Images (26)
Contributors: Elizabeth B. Wallace MD, Susan Burgin MD
Other Resources UpToDate PubMed

Synopsis

Transient acantholytic dermatosis, also known as Grover disease, is an acquired skin disorder of unknown etiology. The disease is found primarily in middle-aged to elderly white men; the male-to-female ratio ranges from 1.8-7:1 in the literature. Although the cause has not been established, the condition has been linked to heat, sweating, excessive sun exposure, ionizing radiation, and some medications, including immunotherapies such as BRAF inhibitors and ipilimumab. One large retrospective study of outpatients found the disease diagnosed 4 times more often in the winter than in the summer and attributed this difference to dry skin. Another study of inpatients found prolonged bed rest as a risk factor. Atopic dermatitis, renal failure, transplantation, and malignancies have also been associated with this diagnosis.

Clinically, transient acantholytic dermatosis presents with red scaly papules and papulovesicles over the trunk. The condition is usually intensely pruritic; however, some patients are completely asymptomatic. Flares of disease may be marked by an increase in both pruritus and surrounding erythema, vesicles, and erosions. This appearance is frequently encountered on the backs of hospitalized patients on prolonged bed rest.

This condition is histologically variable, and the key finding on pathology is focal acantholysis. The disease can be self-resolving or may wax and wane for several years. Since the condition is benign, the primary goal of treatment is control of symptoms.

Codes

ICD10CM:
L11.1 – Transient acantholytic dermatosis [Grover]

SNOMEDCT:
17796002 – Transient acantholytic dermatosis

Look For

Subscription Required

Diagnostic Pearls

Subscription Required

Differential Diagnosis & Pitfalls

Best Tests

Subscription Required

Management Pearls

Subscription Required

Therapy

Subscription Required

Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

Subscription Required

References

Subscription Required

Last Reviewed: 03/02/2017
Last Updated: 04/04/2017
Copyright © 2019 VisualDx®. All rights reserved.
Transient acantholytic dermatosis
Captions OFF Print 26 Images Filter Images
View all Images (26)
(with subscription)
 Reset
Transient acantholytic dermatosis : Rash, Back, Primarily truncal, Pruritus
Clinical image of Transient acantholytic dermatosis
Scattered light pink papules on the upper back.
Copyright © 2019 VisualDx®. All rights reserved.