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Urethritis
Other Resources UpToDate PubMed

Urethritis

Contributors: Neil Mendoza MD, Susan Burgin MD, Paritosh Prasad MD
Other Resources UpToDate PubMed

Synopsis

Urethritis is inflammation of the urethra typically caused by infectious organisms including Chlamydia trachomatis or Neisseria gonorrhoeae. In some cases, urethritis may result from noninfectious conditions or may be idiopathic.

Patients have urethral discharge, which, depending on the etiology of the urethritis, can vary in amount and appearance. In some cases, the discharge may be scant and clear. Gonococcal urethritis typically causes frankly purulent discharge. Patients may also have dysuria or urethral pruritus. In some cases, urethritis may be accompanied by epididymitis (usually unilateral epididymal pain), proctitis (depending on exposure), and/or fever.

Multiple pathogens cause urethritis, including N gonorrhoeae, C trachomatis, Mycoplasma genitalium, and Trichomonas vaginalis. Less common pathogens include Neisseria meningitidis, Neisseria elongata, Ureaplasma spp, Haemophilus influenzae, Haemophilus parainfluenzae, Corynebacterium spp, Kurthia gibsonii, Aerococcus urinae, Epstein-Barr virus, Ureaplasma spp, adenovirus, and herpes simplex virus. In addition, patients should be tested for other sexually transmitted diseases, including HIV, since co-infection is possible (especially in high-risk patient populations).

Codes

ICD10CM:
N34.1 – Nonspecific urethritis

SNOMEDCT:
31822004 – Urethritis

Look For

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

  • Prostatitis or epididymitis due to enteric pathogens (eg, Escherichia coli)
  • Chronic prostatitis / chronic pelvic pain syndrome – Does not present with urethral discharge.
  • Cystitis – Presents with dysuria but not urethral discharge.
  • Chemical irritation (eg, from spermicides)

Best Tests

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Management Pearls

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Therapy

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References

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Last Reviewed:09/19/2021
Last Updated:10/13/2021
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Urethritis
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A medical illustration showing key findings of Urethritis : Dysuria, Urethral discharge
Copyright © 2022 VisualDx®. All rights reserved.