Wiskott-Aldrich syndrome in Infant/Neonate
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Synopsis

Viral (warts, herpes, and molluscum) and bacterial infections occur frequently in infancy and early childhood, most commonly bacterial otitis media, sinusitis, pneumonias, impetigo, cellulitis, and abscesses. Furthermore, WAS patients have a high prevalence of food allergies, asthma, and urticaria. Up to 70% of patients are also found to have autoimmune disorders, including cytopenias, arthritis, and vasculitis. Milder forms of WAS have been described that do not involve the typical immunodeficiencies.
WAS may be further complicated by the development of lymphoreticular malignancies (especially non-Hodgkin lymphoma and Epstein-Barr virus-induced lymphomas) and leukemia in childhood.
Females may have the syndrome due to nonrandom X-chromosome inactivation.
Codes
ICD10CM:D82.0 – Wiskott-Aldrich syndrome
SNOMEDCT:
36070007 – Wiskott-Aldrich syndrome
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Differential Diagnosis & Pitfalls
- Atopic dermatitis
- Seborrheic dermatitis
- Langerhans cell histiocytosis
- Hyperimmunoglobulinemia E syndrome
- Omenn syndrome
- Netherton syndrome
- Severe combined immunodeficiency (SCID)
- IPEX syndrome
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Last Reviewed:06/02/2021
Last Updated:01/25/2022
Last Updated:01/25/2022