ContentsSynopsisCodesBest TestsReferences
Common variable immunodeficiency
Other Resources UpToDate PubMed

Common variable immunodeficiency

Contributors: Michael W. Winter MD
Other Resources UpToDate PubMed

Synopsis

A genetically heterogeneous group of rare diseases associated with significantly increased risk of mortality and marked by hypogammaglobulinemia, a failure to produce antibodies in response to antigens, and repeated bacterial infections. Patients have poor response to antibiotics, illnesses undeterred by vaccinations, and recurrent complicating conditions such as bronchitis, bronchiectasis, sinusitis, bacterial pneumonia, otitis, and pulmonary damage. Diagnosis typically occurs in the first or third decade of life.

Some patients may develop an autoimmune disorder, most commonly either idiopathic thrombocytopenia purpura or autoimmune hemolytic anemia. Lymphadenopathy, splenomegaly, and cancers such as lymphoma and gastric cancer may occur. Most cases are idiopathic; a minority are genetic.

For more information, see OMIM.

Codes

ICD10CM:
D83.9 – Common variable immunodeficiency, unspecified

SNOMEDCT:
23238000 – Common variable agammaglobulinemia

Best Tests

Subscription Required

References

Subscription Required

Last Updated:03/28/2017
Copyright © 2021 VisualDx®. All rights reserved.
Common variable immunodeficiency
Print  
Common variable immunodeficiency : Diarrhea, Failure to thrive, Hypogammaglobulinemia, Otalgia
Copyright © 2021 VisualDx®. All rights reserved.