A deep venous thrombosis (DVT) results when a blood clot forms in the deep veins, often of the lower extremity. DVT may cause pain, erythema, or swelling locally but can also be asymptomatic. It carries the potential for embolization to the lungs (pulmonary embolism), which can precipitate potentially life-threatening cardiopulmonary events including cardiac arrest.
Risk factors for DVT include:
Prior history of DVT
Pelvic / lower extremity trauma
Older than 60
Certain drugs: oral contraceptive pills, hormone replacement therapy, chemotherapy
Endovenous laser ablation or radiofrequency ablation (endovenous heat-induced thrombosis [EHIT])
Once diagnosed, anticoagulation is initiated in efforts to stabilize the existing thrombus, prevent further thrombus aggregation, and allow for dissolution over time. Duration of therapy depends on the inciting etiology and patient substrate. Barring any contraindication to anticoagulation, treatment should be initiated urgently once the condition is diagnosed to prevent clot extension or pulmonary embolism.
ICD10CM: I80.209 – Phlebitis and thrombophlebitis of unspecified deep vessels of unspecified lower extremity
SNOMEDCT: 128053003 – Deep vein thrombosis
Differential Diagnosis & Pitfalls
Abscess (see , )
Injury – pulled muscles or tendons
Other causes of peripheral edema such as , , , hypoalbuminemia
Drug Reaction Data
Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.