ContentsSynopsisCodesLook ForDiagnostic PearlsDifferential Diagnosis & PitfallsBest TestsManagement PearlsTherapyDrug Reaction DataReferencesInformation for Patients
Duodenal ulcer
Print
Other Resources UpToDate PubMed

Duodenal ulcer

Print Patient Handout Images (1)
Contributors: Michael W. Winter MD, Khaled Bittar MD, Nishant H. Patel MD, Desiree Rivera-Nieves MD
Other Resources UpToDate PubMed

Synopsis

A duodenal ulcer is a form of peptic ulcer disease. It is defined by a mucosal defect extending through the muscularis mucosa in the intestinal lining. Duodenal ulcers are at risk for eroding into blood vessels, leading to gastrointestinal bleeding.

The most common cause of duodenal ulcer is mucosal injury due to chronic infection from Helicobacter pylori. Nonsteroidal anti-inflammatory drugs (NSAIDs) are the second most common cause of duodenal ulcer. Smoking is a strong risk factor for developing ulcers. There are other much less common causes including Zollinger-Ellison syndrome.

Patients can present with a variety of symptoms from duodenal ulcers. Epigastric abdominal pain and dyspepsia are most common. If eroded into a blood vessel, hematemesis, melena, or rarely bright red blood per rectum (if there is brisk bleeding) can be presenting symptoms.

Helicobacter pylori is a common worldwide infection predisposing to duodenal ulcers. Untreated, it is also a carcinogen associated with the development of gastric cancer.

Patients with concern for a duodenal ulcer, whether bleeding or not bleeding, should undergo an esophagogastroduodenoscopy (EGD) to confirm the diagnosis.

Codes

ICD10CM:
K26.9 – Duodenal ulcer, unspecified as acute or chronic, without hemorrhage or perforation

SNOMEDCT:
51868009 – Duodenal ulcer disease

Look For

Subscription Required

Diagnostic Pearls

Subscription Required

Differential Diagnosis & Pitfalls

Best Tests

Subscription Required

Management Pearls

Subscription Required

Therapy

Subscription Required

Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

Subscription Required

References

Subscription Required

Last Reviewed: 05/24/2017
Last Updated: 06/07/2017
Copyright © 2019 VisualDx®. All rights reserved.
Duodenal ulcer
Print 1 Images
Duodenal ulcer : Nausea, Vomiting, Epigastric pain, Recurring episodes or relapses, Melena, Dyspepsia
Copyright © 2019 VisualDx®. All rights reserved.