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Eosinophilic annular erythema
Other Resources UpToDate PubMed

Eosinophilic annular erythema

Contributors: David O'Connell MD, Lisa Zaba MD, PhD, Susan Burgin MD
Other Resources UpToDate PubMed


Eosinophilic annular erythema (EAE) is a rare eosinophilic dermatosis of unknown origin. It is seen most commonly in adults, but children can be affected as well. There are no established risk factors, including sex or racial or ethnic predilections. Most likely a reactive phenomenon, it is possibly related to annular erythema of infancy (AEI) or, as some suspect, on a spectrum with eosinophilic cellulitis (EC), also known as Wells syndrome.

EAE is marked by a recurrent, asymptomatic or pruritic, annular or gyrate erythema primarily affecting the torso and proximal extremities. Reported associated diseases include chronic hepatitis C, autoimmune pancreatitis, diabetes mellitus, chronic renal disease, chronic gastritis with helicobacter pylori infection, and some solid tumors (thymoma, prostate cancer, and renal cell cancer).


L53.9 – Erythematous condition, unspecified

200920000 – Annular erythema

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Differential Diagnosis & Pitfalls

  • Urticarial vasculitis – EAE lesions are larger.
  • Subacute cutaneous lupus erythematosus – EAE is not photosensitive and is not scaly.
  • Tumid lupus erythematosus
  • Erythema annulare centrifugum – Typically has trailing scale.
  • Tinea corporis – Look for scale and do a confirmatory potassium hydroxide (KOH) preparation. 
  • Erythema gyratum repens
  • Erythema multiforme – Typically these lesions are smaller and more peripheral.
  • Erythema marginatum
  • Glucagonoma syndrome – There are prominent erosions and/or bullae at active borders.
  • Urticarial phase of Bullous pemphigoid

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Last Reviewed:05/23/2022
Last Updated:05/24/2022
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Eosinophilic annular erythema
A medical illustration showing key findings of Eosinophilic annular erythema : Abdomen, Back, Eosinophilia, Primarily truncal distribution, Annular configuration
Copyright © 2024 VisualDx®. All rights reserved.