Liver cancer
Alerts and Notices
Synopsis

There are several rare types of liver cancer. Angiosarcoma and epithelioid hemangioendothelioma arise from mesenchymal cells. Intraductal papillary neoplasm and mucinous cystic neoplasm with invasive carcinoma arise from the bile ducts.
Hepatoblastoma is another primary liver malignancy arising from hepatocytes. This cancer is more common in children younger than 3 years old. It is associated with some genetic conditions, such as Beckwith-Wiedemann syndrome, Wilson disease, and familial adenomatous polyposis.
Many malignancies can metastasize to the liver. Frequently, patients with uveal melanoma may have liver metastases. In rare circumstances, lymphomas can present with primary manifestation in the liver.
Codes
ICD10CM:C22.9 – Malignant neoplasm of liver, not specified as primary or secondary
SNOMEDCT:
93870000 – Malignant neoplasm of liver
Look For
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Diagnostic Pearls
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Differential Diagnosis & Pitfalls
- Hepatic cysts
- Hepatic abscess
- Choledocholithiasis
- Primary sclerosing cholangitis
- Primary biliary cholangitis
- Embryonal sarcoma
- Cystadenocarcinoma in intrahepatic bile ducts
- Liver hemangioma
- Focal nodular hyperplasia
- Rhabdomyosarcoma
- Angiomyolipoma
- Hepatic adenoma – A benign lesion, generally uncommon but more common among women than men. Risk factors include long-term oral contraceptive use and estrogen exposure during pregnancy. Up to 30% of cases are complicated by bleeding.
Best Tests
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Management Pearls
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Therapy
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References
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Last Reviewed:03/27/2018
Last Updated:01/31/2023
Last Updated:01/31/2023