Melkersson-Rosenthal syndrome - Oral Mucosal Lesion
Orofacial granulomatosis is also known as cheilitis granulomatosa or granulomatous cheilitis and may be associated with hypersensitivity to some foods and food additives (in particular benzoates and cinnamon products), sensitivities to amalgam, Crohn disease, and sarcoidosis. If no specific etiology can be identified (eg, after patch testing or evaluation for systemic disease), the condition is deemed idiopathic. However, orofacial granulomatosis may be the first manifestation of Crohn disease, with gastrointestinal signs and symptoms occurring years later.
Orofacial granulomatosis typically presents in the late second decade but has been reported in children as young as 5 years of age. Some studies demonstrate an increased incidence in females compared with males, while other studies do not show a difference. No ethnic predilection has been shown. Most patients first develop intermittent asymptomatic swelling of the lips. Eventually, the swelling becomes persistent. Rarely, patients develop facial palsy first. Other associated neurologic and ophthalmologic symptoms include migraine headaches, tinnitus, dizziness, vision disturbances, and excessive tearing. Involvement of the facial nerve by granulomas is what leads to facial nerve palsy.
G51.2 – Melkersson's syndrome
37770007 – Melkersson-Rosenthal syndrome
- Allergic contact dermatitis / stomatitis – This is almost always associated with redness of the skin or mucosa.
- Angioedema – Acute swelling that completely resolves within 24-48 hours. May have associated airway involvement.
- Ascher syndrome – Inherited condition with swelling of lips and eyelids.
- Crohn disease – Orofacial granulomatosis may precede overt manifestations of Crohn disease by years.
- Infection – This would be acute in onset and acutely painful (see, eg, cellulitis).
- Sarcoidosis – This may present with granulomas of the salivary glands in the lips and gingival swelling.