Orbital lymphoma - External and Internal Eye
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Synopsis
Orbital lymphoma makes up 55% of all orbital malignancies and has been reported to make up between 1% and 10% of all non-Hodgkin lymphomas. It can present unilaterally or bilaterally and typically affects older adult patients between their fifth and seventh decades. It is most commonly reported in Asia and Europe.
Symptoms include double vision, eyelid swelling, proptosis, difficulty with eye movement, redness, and rarely pain.
The most reported risk factor is immunosuppression such as AIDS, status post-organ transplant, and increasing age. Recent associations with infections, autoimmune conditions, and genetic factors have been reported in varying degrees. The associated infections include Chlamydia species, Helicobacter pylori, and Epstein-Barr virus. The associated autoimmune conditions include rheumatoid arthritis, Graves disease, and Sjögren syndrome.
Codes
ICD10CM:C69.60 – Malignant neoplasm of unspecified orbit
SNOMEDCT:
13048006 – Orbital lymphoma
Look For
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Diagnostic Pearls
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Differential Diagnosis & Pitfalls
- Lymphoid lesions of the orbit – benign reactive lymphoid hyperplasia, atypical lymphoid hyperplasia, diffuse lymphangioma (see pseudolymphoma)
- Lacrimal adenoma
- Cavernous hemangioma
- Intraocular orbital inflammation
- Orbital metastases
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Management Pearls
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Therapy
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References
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Last Reviewed:12/30/2019
Last Updated:05/05/2020
Last Updated:05/05/2020