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Emergency: requires immediate attention
Osteomyelitis in Adult
See also in: Cellulitis DDx
Other Resources UpToDate PubMed
Emergency: requires immediate attention

Osteomyelitis in Adult

See also in: Cellulitis DDx
Contributors: David L. Coffman, Susan Burgin MD, Johannes Plate MD, PhD
Other Resources UpToDate PubMed

Synopsis

Osteomyelitis is an inflammatory process of bone secondary to an infection, most commonly bacterial. Osteomyelitis can be caused by contiguous spread of infection from adjacent soft tissues and joints, hematogenous seeding, or direct inoculation of microorganism(s) into the bone as a result of trauma or surgery. Osteomyelitis can complicate ulcers, especially diabetic foot ulcers and decubitus ulcers.

Signs and symptoms include fever, malaise, swelling, erythema, tenderness, and decreased range of motion.

Causes / typical injury mechanism: The mechanism by which osteomyelitis occurs varies with nonhematogenous versus hematogenous osteomyelitis.
  • Nonhematogenous osteomyelitis occurs as a result of bacteria reaching the bones either via contact with an adjacent soft tissue infection or via direct inoculation (eg, via trauma such as open long bone fractures, surgery, or a bite wound).
  • Hematogenous osteomyelitis occurs from inoculation of bone tissue with bacteria from the blood. This typically happens in the setting of bacteremia and/or endocarditis and is much more common in children.
Classic history and presentation: Nonhematogenous and hematogenous clinical presentations are usually indistinguishable, although there are some exceptions.

Acute cases of osteomyelitis usually have a gradual onset over the course of several days. The following symptoms are typically present at or within the vicinity of the site of infection:
  • Dull pain / tenderness that may or may not be exacerbated by movement
  • Warmth
  • Swelling
  • Erythema
In addition, a patient presenting with acute osteomyelitis may be febrile with general malaise.

Chronic cases of osteomyelitis may have the same symptoms as acute cases, but pain, erythema, swelling, and other local symptoms might be intermittent in nature. The presence of a sinus tract, a connection between the area of osteomyelitis and the skin, is pathognomonic of chronic osteomyelitis. There may be other surrounding soft tissue insults such as soft tissue / skin ulcerations or diabetic ulcerations. Chronic osteomyelitis can be accompanied by the presence of necrotic bone (sequestrum) that may be surrounded by thickened reactive periosteal bone (involucrum).

Prevalence:
  • Age – As an individual ages, the general risk for osteomyelitis increases. Additionally, the locations and pathogenesis of the disease change with age. Generally, pediatric patients will have hematogenous osteomyelitis, although hematogenous osteomyelitis of the vertebral bodies is more common in adults.
  • Sex / gender – Men seem to be at higher risk.
Risk factors: Risk factors can be separated into systemic and local.

Systemic risk factors include:
Local risk factors include:
  • Hypoperfusion to the infected region
  • Venous stasis
  • Presence of surgical components
  • Poorly healing soft tissue wounds
Pathophysiology: By definition, osteomyelitis involves a bacterial infection of bone tissue accompanied by destruction of bone tissue and the associated inflammatory response. Nonhematogenic infections can be either monomicrobial or polymicrobial, while hematogenic infections are usually monomicrobial as this type of osteomyelitis arises secondary to bacteremia. It is important to note that negative blood cultures do not necessarily rule out osteomyelitis given the disease can occur after the infection is cleared from the blood.

The most common causative agent by far of osteomyelitis is Staphylococcus aureus (including methicillin-resistant S aureus [MRSA]). Other common causes include coagulase negative staphylococci (eg, Staphylococcus epidermidis) and aerobic gram-negative bacilli (eg, Pseudomonas aeruginosa). Corynebacteria, fungal species, and mycobacteria are less common causes.

Some species are associated with different underlying conditions:
  • Staphylococcus aureus and S epidermidis are associated with IV drug users and patients who have had recent surgery and/or trauma.
  • Pseudomonas aeruginosa is associated with diabetic patients.
  • Salmonella spp, Streptococcus pneumoniae, and other encapsulated organisms can be associated with sickle cell disease.
  • Common organisms responsible for the nosocomial setting include Enterobacteriaceae, P aeruginosa, and Candida spp.
  • Fungal infections are especially associated with disseminated disease, which usually affects immunocompromised patients.
  • In patients with a history of human or animal bites, consider infection with Pasteurella multocida.
The exact pathophysiology will vary depending on the causative agent, but bacterial adherence and resistance to host defenses are some of the more important virulence factors of bacteria that are able to cause osteomyelitis.

Additional features of pathogenesis include superlative infective processes and accompanying inflammatory features, vascular congestion / small vessel thrombosis, necrotic bone, and formation of new bone. Furthermore, the presence of polymorphonuclear leukocytes and other inflammatory cells plays an important role in the pathogenesis of the disease.

Grade / classification system: Generally, osteomyelitis is classified by the source of the infection (ie, hematogenous or nonhematogenous) or by duration of the condition (ie, acute or chronic).

Of these classifications, osteomyelitis secondary to a contiguous infection (eg, after surgery, insertion of orthopedic hardware, or trauma) is the most common. The next most common cause is vascular insufficiency (eg, diabetic foot infections). Hematogenous origin is the least common cause of osteomyelitis, except in children in whom it is the most common form.

Classification based on the type of bone infected can also be useful, since approaches to treatment are different based on the bone type infected, specifically, long bone versus sternoclavicular versus vertebral versus pelvic versus sacral infection.

Treatment of chronic osteomyelitis includes surgical debridement of any necrotic bone or tissue followed by culture-directed antibiotic therapy. A sequestrum needs to be removed or chronic osteomyelitis may continue or reoccur. Acute osteomyelitis is frequently treatable with antibiotics alone.

Codes

ICD10CM:
M86.9 – Osteomyelitis, unspecified

SNOMEDCT:
60168000 – Osteomyelitis

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Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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Last Reviewed:07/25/2021
Last Updated:08/04/2021
Copyright © 2021 VisualDx®. All rights reserved.
Emergency: requires immediate attention
Osteomyelitis in Adult
See also in: Cellulitis DDx
Osteomyelitis : Fever, Erythema, Inability to bear weight, Malaise, Skin ulcer, Limb pain
Clinical image of Osteomyelitis
Copyright © 2021 VisualDx®. All rights reserved.