Peripheral ulcerative keratitis - External and Internal Eye
- Rheumatoid arthritis
- Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitidies:
- Systemic lupus erythematosus
- Relapsing polychondritis
PUK affects 3 persons per million per year. There is no gender predilection, but PUK more commonly affects patients after their fourth or fifth decade.
Patients present with ocular redness, pain, tearing, photophobia, and decreased vision. The classic presentation is a crescent-shaped white ulcer on the peripheral edge of the cornea.
Cases are mostly unilateral but can be bilateral. About 36%-66% of PUK cases can be associated with a scleritis, and a wider incidence of cases can be associated with anterior uveitis. The worst complications of PUK are corneal perforation or scleral perforation from an associated necrotizing scleritis. These complications need immediate surgical intervention to prevent infection and vision loss.
H16.009 – Unspecified corneal ulcer, unspecified eye
416473005 – Peripheral ulcerative keratitis
- Terrien's marginal degeneration
- Pellucid marginal degeneration
- Furrow degeneration
- Staphylococcal marginal keratitis (see bacterial keratitis)
- Phlyctenular keratoconjunctivitis
- Vernal keratoconjunctivitis
- Infectious ulcers (see bacterial corneal ulcer, fungal corneal ulcer)
- Mooren ulcer (can be associated with hepatitis C virus infection)
- Exposure keratopathy
- Neurotrophic keratoconjunctivitis
- Surgical complications