Prurigo nodularis in Child
Alerts and Notices
Synopsis

Prurigo nodularis may be secondary to skin conditions associated with pruritus, such as atopic dermatitis and xerosis, as well as systemic conditions associated with generalized pruritus without a primary skin rash, such as psychiatric conditions, eating disorders, HIV infection, iron-deficiency anemia, diabetes mellitus, gluten enteropathy, thyroid disease, renal or hepatic impairment, malignancies, and others. In most cases, the etiology of pruritus is unknown. Studies have suggested that prurigo nodularis may be a form of subclinical small fiber neuropathy and that Th2 cytokines play an important role in its pathogenesis.
Lesions are firm dome-shaped, smooth-topped, or crusted nodules. Their size ranges from several millimeters to 1-2 cm, and they often enlarge slowly over time. Lichenification of the lesions is often not present.
Patients with this disorder may have an increased risk of various general medical conditions.
Codes
ICD10CM:L28.1 – Prurigo nodularis
SNOMEDCT:
63501000 – Prurigo nodularis
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Diagnostic Pearls
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Differential Diagnosis & Pitfalls
Top considerations:- Hypertrophic lichen planus
- Nodular scabies
- Keloids
- Acne keloidalis nuchae
- Cutaneous horn
- Hypertrophic scars
- Various types of lymphoma
- Pseudolymphoma
- Lymphomatoid papulosis
- Warts
- Molluscum contagiosum
- Mastocytomas
- Dermatofibromas
- Pilomatricomas
- Foreign body reactions
- Xanthomas (eruptive xanthoma, xanthoma tuberosum)
- Knuckle pads
- Multicentric reticulohistiocytosis
- Persistent insect bite reaction
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References
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Last Reviewed:03/01/2021
Last Updated:03/01/2021
Last Updated:03/01/2021