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Spiny keratoderma
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Spiny keratoderma

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Contributors: Ailia Ali MD, Susan Burgin MD
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Synopsis

Spiny keratoderma, also known as music box spine keratosis and palmoplantar filiform hyperkeratosis, is a rare form of punctate palmoplantar keratoderma characterized by pinpoint keratotic projections on the palms and soles.

Spiny keratoderma may be inherited or acquired. The hereditary form is inherited in an autosomal dominant manner with onset typically in childhood. Acquired spiny keratoderma usually manifests after age 50. It has been associated with various malignancies, including renal, pulmonary, and gastrointestinal carcinomas, as well as lymphoproliferative malignancies and melanoma. Other reported underlying disease associations have included polycystic kidney disease, chronic renal failure, type 4 hyperlipoproteinemia, and pulmonary tuberculosis. It has been suggested that acquired spiny keratoderma may predate the diagnosis of a malignancy and that heightened malignancy screening is needed after its diagnosis.

There does not appear to be a gender or racial predilection for spiny keratoderma.

Codes

ICD10CM:
Q82.8 – Other specified congenital malformations of skin

SNOMEDCT:
402773000 – Punctate palmoplantar keratoderma

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Last Reviewed: 10/10/2018
Last Updated: 10/30/2018
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Spiny keratoderma
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Spiny keratoderma : Palms and soles, Symmetric extremities
Copyright © 2019 VisualDx®. All rights reserved.