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Vasculitis - External and Internal Eye
See also in: Overview,Cellulitis DDx
Other Resources UpToDate PubMed

Vasculitis - External and Internal Eye

See also in: Overview,Cellulitis DDx
Contributors: Brandon D. Ayres MD, Christopher Rapuano MD, Harvey A. Brown MD, Sunir J. Garg MD, Lauren Patty Daskivich MD, MSHS
Other Resources UpToDate PubMed

Synopsis

Vasculitis is a nonspecific term that encompasses a large and heterogeneous group of disorders that are characterized by inflammation of blood vessels. No uniform classification system for vasculitis exists, although subtypes are often categorized by the size of the vessels involved, the type of circulating immune complexes, and other histopathologic and clinical features. In many cases, damage to the blood vessels results in leakage of red blood cells and the development of palpable purpura on the skin. Other common cutaneous signs of vasculitis include skin ulcerations, Raynaud phenomenon, and livedo reticularis. It is important to distinguish a primary systemic vasculitis from one associated with medications, infection, malignancy, or a connective tissue disorder, as the best course of treatment may be different.

Several types of systemic vasculitis can affect the eye. Ocular complications can include uveitis, scleritis, keratitis, and optic neuropathy. Granulomatosis with polyangiitis can affect the eye in up to 40% of cases. Systemic lupus erythematosus, rheumatoid arthritis, Takayasu arteritis, and polyarteritis nodosa can all cause vasculitis with retinal and anterior segment involvement.

The lesions of vasculitis are often multifocal and/or bilateral. Ulceration, palpable purpura, and livedo reticularis may be present. Be sure to ask the patient about the presence of specific symptoms such as myalgias, arthralgias, hematuria, or neuropathy.

Codes

ICD10CM:
L95.9 – Vasculitis limited to the skin, unspecified

SNOMEDCT:
31996006 – Vasculitis

Look For

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

Best Tests

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Management Pearls

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Therapy

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Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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References

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Last Updated:10/25/2017
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Vasculitis - External and Internal Eye
See also in: Overview,Cellulitis DDx
Vasculitis : Malaise, p-ANCA positive, Palpable purpura, Symmetric extremities distribution, Arthralgia, Myalgia, CRP elevated, ESR elevated
Clinical image of Vasculitis
A close-up of palpable purpura.
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