Wiskott-Aldrich syndrome in Child
Viral (warts, herpes, and molluscum) and bacterial infections occur frequently in infancy and early childhood, most commonly bacterial otitis media, sinusitis, pneumonias, impetigo, cellulitis, and abscesses. Furthermore, WAS patients have a high prevalence of food allergies, asthma, and urticaria. Up to 70% of patients are also found to have autoimmune disorders, including cytopenias, arthritis, and vasculitis. Milder forms of WAS have been described that do not involve the typical immunodeficiencies.
WAS may be further complicated by the development of lymphoreticular malignancies (especially non-Hodgkin lymphoma and Epstein-Barr virus-induced lymphomas) and leukemia in childhood.
Females may have the syndrome due to nonrandom X-chromosome inactivation.
D82.0 – Wiskott-Aldrich syndrome
36070007 – Wiskott-Aldrich syndrome
Differential Diagnosis & Pitfalls