A 48-year-old woman visited her doctor for fat loss that affected her lower extremities and an accumulation of abdominal fat that developed over 3 months. On examination, subcutaneous atrophy was present on her legs, excess fat in the intraabdominal areas was pronounced, and a buffalo hump was visible on the back of her neck. The patient was HIV-infected and had been on combination antiretroviral therapy (ART) that was comprised of tenofovir, emtricitabine, and efavirenz for 2.5 years.
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